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Myo-Inositol

What Huberman said

Huberman says he takes inositol and that it greatly enhances his sleep; he describes 900 mg myo-inositol every other night (every third night or so in his 2022 brain-chemistry episode, replayed in a 2026 Essentials), after which he finds it very easy to fall back asleep if he wakes in the night. He says it also has a long tail of anxiety suppression through the day and can increase serotonin and other neurochemicals. Separately, he describes studies where a fairly high dose (18 g for a full month) produced a very notable drop in anxiety symptoms, with a potency he calls on par with many prescription antidepressants, and says improvement takes time.

Doses, as he worded them

  • “900 milligrams of myo-inositol”[2]

    every other night, his own use

  • “900 milligrams of myo-inositol every third night or so”[3]

    his own test, for sleep

  • “18 grams of Inositol taken for a full month”[5]

    dose he describes for anxiety ('a fairly high dose'); not a personal protocol

Quoted, not prescribed. Talk to a doctor or pharmacist first if you take medication, are pregnant or have a health condition.

Cautions he mentions

  • No supplement should ever be used as a direct replacement for prescription serotonin treatments.[3]
  • You probably would not want to take it during or prior to a (therapy) session where you are trying to amplify and recount an experience in order to extinguish it.[5]

Where he said it

  1. 1
    “I also take inositol. It greatly enhances my sleep.”

    Developing a Rational Approach to Supplementation for Health & Performance

    Episode · 00:58:11 · 2023

    Watch from 00:58:11Episode page
  2. 2
    “Every other night, I'll take 900 milligrams of myo-inositol”

    Sleep Toolkit: Tools for Optimizing Sleep & Sleep-Wake Timing

    Episode · 01:17:44 · 2022

    Watch from 01:17:44Episode page
  3. 3
    “I've been taking 900 milligrams of myo-inositol every third night or so as a test of its ability to improve sleep”

    Essentials: Control Your Brain Chemistry for Focus, Motivation & Well-Being

    Episode · 00:28:02 · 2026

    Watch from 00:28:02Episode page
  4. 4
    “The first is myo-inositol, typically taken as 900 milligrams of myo-inositol.”

    Developing a Rational Approach to Supplementation for Health & Performance

    Episode · 00:43:45 · 2023

    Watch from 00:43:45Episode page
  5. 5
    “Inositol has been shown to create a very notable decrease in anxiety symptoms.”

    Essentials: Erasing Fears & Traumas Using Modern Neuroscience

    Episode · 00:31:10 · 2025

    Watch from 00:31:10Episode page

Part of his stacks

Related

This page reports what Andrew Huberman has said. It isn’t medical advice and NSDR.co isn’t affiliated with Huberman Lab. Talk to a doctor or pharmacist first if you take medication, are pregnant or have a health condition. Safety information