Fadogia Agrestis
This entry is being reviewed. We could not yet check its doses and interactions against independent sources, so read it as a record of what was said, not as guidance.
What Huberman said
Huberman says he has taken fadogia agrestis at 600 mg a day, cycled about 8 to 12 weeks on and a few weeks off, and describes it as increasing luteinising hormone and thereby testosterone (and estrogen); he says at that dose many people, though not all, report elevated libido. He warns it can be toxic to testicular cells at very high dosages, that its side-effect profile hasn't really been documented, and that blood work is extremely important for safety.
Doses, as he worded them
“600 milligrams per day”[1]
his own dose, cycled; he says many people report elevated libido at this dose
Quoted, not prescribed. Talk to a doctor or pharmacist first if you take medication, are pregnant or have a health condition.
Cautions he mentions
- Fadogia agrestis can be toxic to testicular cells and perhaps other cells when taken at very high dosages.[2]
- Cycling: he says some people need to cycle it eight weeks on, two weeks off; others opt for 12 weeks on, a month off.[2]
- Get blood work after about four to eight weeks of taking it to see whether it is affecting your hormones.[2]
- He says he has heard of potential toxicity to testicular cells, cycles it 8-12 weeks on and a few weeks off, and was thinking maybe three times per week or every other day might be better.[1]
- Its side-effect profile hasn't really been documented, so it's a little unclear.[3]
- Getting blood work done is extremely important for safety reasons.[3]
Safety notes from independent sources
- We found no human safety studies of Fadogia agrestis. In rats given an aqueous stem extract for 28 days, markers of testicular function changed at every dose tested (18, 50 and 100 mg/kg). Yakubu et al. 2008, J Ethnopharmacol (animal study)
Where he said it
- 1
“I've been cycling it for about 8 to 12 weeks on and then a few weeks off.”
Dr. Kyle Gillett: Tools for Hormone Optimization in Males
Episode · 01:22:09 · 2022
- 2
“Fadogia agrestis can be toxic to testicular cells and perhaps other cells when taken at very high dosages.”
Developing a Rational Approach to Supplementation for Health & Performance
Episode · 01:16:04 · 2023
- 3
“The side effect profile of Fadogia agrestis hasn't really been documented”
Essentials: How to Optimize Testosterone & Estrogen
Episode · 00:27:02 · 2025
Related
This page reports what Andrew Huberman has said. It isn’t medical advice and NSDR.co isn’t affiliated with Huberman Lab. Talk to a doctor or pharmacist first if you take medication, are pregnant or have a health condition. Safety information