He takes itFocus
Huperzine A
What Huberman said
Huberman lists huperzine alongside alpha-GPC as supplements he has used and does use to increase acetylcholine (said in 2022 and replayed in a 2026 Essentials episode). He says it works mainly on the enzymatic pathway, and gives no dose in these sources.
Safety notes from independent sources
- Huperzine A is a natural cholinesterase inhibitor. Rafii et al. 2011, Neurology
- It is an approved drug in some countries. Reported effects include a slower heart rate, nausea and dizziness. The Alzheimer's Association recommends not taking it, especially with prescription drugs. Operation Supplement Safety (US DoD): Huperzine A
Where he said it
- 1
“Supplements that I have used and do use for increasing acetylcholine are things like Alpha-GPC or Huperzine.”
Essentials: Control Your Brain Chemistry for Focus, Motivation & Well-Being
Episode · 00:24:40 · 2026
- 2
“Whereas huperzine is mainly in the enzymatic pathway.”
Optimize & Control Your Brain Chemistry to Improve Health & Performance
Episode · 01:37:29 · 2022
Related
This page reports what Andrew Huberman has said. It isn’t medical advice and NSDR.co isn’t affiliated with Huberman Lab. Talk to a doctor or pharmacist first if you take medication, are pregnant or have a health condition. Safety information